Package: MixTwice
Type: Package
Title: Large-Scale Hypothesis Testing by Variance Mixing
Version: 2.0
Imports: alabama, ashr, fdrtool, Iso, stats
Date: 2022-02-28
Author: Zihao Zheng and  Michael A.Newton
Maintainer: Zihao Zheng <zihao.zheng@wisc.edu>
Description: Implements large-scale hypothesis testing by variance mixing. It takes two statistics per testing unit -- an estimated effect and its associated squared standard error -- and fits a nonparametric, shape-constrained mixture separately on two latent parameters. It reports local false discovery rates (lfdr) and local false sign rates (lfsr). Manuscript describing algorithm of MixTwice: Zheng et al(2021) <doi: 10.1093/bioinformatics/btab162>.
License: GPL-2
NeedsCompilation: no
Packaged: 2022-03-02 16:05:34 UTC; appli
Depends: R (>= 3.5.0)
Repository: CRAN
Date/Publication: 2022-03-02 16:50:02 UTC
Built: R 4.4.3; ; 2025-10-08 02:17:52 UTC; windows
